renal fibrosis — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T13865	Resorcinolnaphthalein		RAAS
	Resorcinolnaphthalein is a specific enhancer of angiotensin-converting enzyme 2 (ACE2) (EC50 value of 19.5 μM).		RAAS
T12883	Fezagepras	PBI-4050,Setogepram	GPR
	Fezagepras (Setogepram) is an orally active GPR40 agonist and is an antagonist or inverse agonist of GPR84 with anti-inflammatory, anti-fibrotic, and anti-proliferative actions.		GPR
T4583	PFI-2 hydrochloride	(R)-PFI-2 hydrochloride,PFI-2 HCl	Histone Methyltransferase
	PFI-2 hydrochloride ((R)-PFI-2 hydrochloride) is a potent, highly selective, and cell-active inhibitor of the methyltransferase activity of SETD7 (IC50: 2 nM), 500 fold active than (S)-PFI-2.		Histone Methyltransferase
T16708	R-268712		ALK , TGF-beta/Smad
	R-268712 is a specific activin receptor-like kinase 5 (ALK5) inhibitor(IC50 of 2.5 nM). It is also an orally active transforming growth factor-β type I receptor inhibitor.		ALK , TGF-beta/Smad
T3033	Deoxycorticosterone acetate	DOC acetate,Cortexone acetate,11-Deoxycorticosterone acetate	Glucocorticoid Receptor , Endogenous Metabolite , Adrenergic Receptor
	Deoxycorticosterone acetate (Cortexone acetate) is the 21-acetate derivative of desoxycorticosterone, used for intramuscular injection for replacement therapy of the adrenocortical steroid.
T1987	PFI-2	PFI2,PFI 2,(R)-PFI-2	Histone Methyltransferase
	PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other methyltransferases and other non-epigenetic targets.		Histone Methyltransferase
T14076	A 839977	A839977,A-839977	P2X Receptor , Calcium Channel
	A 839977 is a selective P2X7 receptor antagonist with anti-inflammatory and analgesic activity that inhibits BzATP-induced calcium efflux from the P2X7 receptor for the study of renal fibrosis.		P2X Receptor , Calcium Channel
T16886	Sinefungin	Adenosyl-Ornithine,A-9145,Antibiotic 32232RP	Others , Histone Methyltransferase , Antibiotic , Antifungal
	Sinefungin (Adenosyl-Ornithine) is an effective inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication. Sinefungin is a SET7/9 inhibitor and ameliorates r...
T9953	BT173		Others
	BT173 is a novel inhibitor of homeodomain interacting protein kinase 2 (HIPK2 ), attenuating renal fibrosis through suppression of the TGF-ß1/Smad3 pathway.		Others
T24270	KS370G	KS-370-G,KS 370 G,Caffeic Acid Phenethyl Amide
	KS370G (Caffeic Acid Phenethyl Amide) inhibits UUO-induced renal fibrosis marker expression. KS370G is an orally active hypoglycemic and cardioprotective agent that reduces collagen deposition in obstructed kidneys and s...
T15300	Fluorofenidone	AKF-PD	Others
	Fluorofenidone (AKF-PD) attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and extracellular matrix (ECM) deposition via the PI3K/Akt signalling pathway. Fluorofenidone is an an...		Others
T3S1227	Aristolactam I	Aristolactam,Aristololactam I,Aristololactum	Apoptosis , Caspase
	1.Aristolactam I (Aristololactum) has cytotoxic potency, mediated through the induction of apoptosis in a caspase 3-dependent pathway. 2. The effects of Aristololactam I may be mediated by different mechanisms except TGF...		Apoptosis , Caspase
T2S2043	Dracorhodin perchlorate	Dracorhodin perochlorate,Dracohodin perochlorate	Apoptosis , Others
	Dracorhodin perchlorate inhibits cell growth, and induces apoptosis in fibroblasts in a dose-and time-dependent manner, arresting cell cycle at G1 phase, may as a candidate for anti-breast cancer. Dracorhodin perchlorate...		Apoptosis , Others
T72798	Ganodermaones B
	Ganodermaones B is a renal fibrosis inhibitor. Ganodermaones B inhibits TGF-β1-induced collagen I and fibronectin expression .
T80072	Des-Arg9-[Leu8]-Bradykinin acetate		Bradykinin Receptor
	Des-Arg9-[Leu8]-Bradykinin acetate is a potent antagonist of the bradykinin receptor 1 (B1R), utilized in renal fibrosis research [1].		Bradykinin Receptor
T79516	BT424		Src
	BT424, a specific HCK inhibitor, modulates macrophage activation and autophagy in vitro, and mitigates inflammation and renal fibrosis in the UUO model [1].		Src
T70932	L6H9
	L6H9 is a novel inhibitor of myeloid differentiation factor 2 (MD2), suppressing HG-induced expression of ACE and AT1 receptor and Angiotensin II (AngII) production in renal NRK‐52E cells, resulting in the decrease in fi...
T73088	Mavodelpar	HPP593,REN001,REN001 ; HPP593
	Mavodelpar (REN001), a selective PPARδ agonist, effectively suppresses glomerular injury and renal fibrosis. It is utilized in the research of primary mitochondrial myopathies (PMM) and long-chain fatty acid oxidation di...
TN3753	Dalbergioidin		Tyrosinase , ROS , Akt , PI3K , TGF-beta/Smad
	Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM. It shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyces bikiniensis that has commonly been used as an indicator or...		Tyrosinase , ROS , Akt , PI3K , TGF-beta/Smad
TMA1743	Ergosterol peroxide		ERK , VEGFR , p38 MAPK , Wnt/beta-catenin , Akt , JAK , CDK , JNK , STAT , Antifection
	Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Foxo3a activity by inhibiting pAKT and c-Myc and activating pr...